I've fortunately never had a serious repetitive motion problem, given that I live on the internet, but too many mouse clicks do start to cause me some discomfort. That's when I know it's time to step away from the internet for a bit. I don't claim to be representative of internet users, but when sites require
too much clicking I tend to read them much less. There's probably some aesthetic justification for paginating really long articles, but don't make me click to read paragraph 2 of a 2 paragraph blog post.