One reason the (likely) failure to nominate Yellen as the next Fed Chief is such a disappointment is that it will miss an incredible opportunity to give the job to a woman for the first time. She has the experience. No one really denies she's qualified, except to suggest she's insufficiently bro-y. And these opportunities don't come up all the time. Due to historical extreme explicit discrimination against women, and existing barriers (including discrimination) big and small, fewer women rise up close enough to the top that getting the top job is realistic. It's reason enough to give her the job. It's an opportunity.
It is, I think, one reason for the disappointment of some Hillary Clinton supporters in 2008. While it hopefully happens more and more, at the moment the likelihood of women getting close enough to reach the top is just lower. One only has to look at the gender balance of governors and senators, the people who have a realistic shot at getting the nomination, to see this. Of course a similar issue existed for her main opponent at the time.