I for one don't believe that snarlin' Arlen is going to be strong enough (or care enough) to make a serious attempt to derail anti-choice judicial appointments, no matter what noises to that effect he's making. There's chum in the water right now, and the sharks will swim straight for him if he holds firm (I don't even believe he intends to, but happy to be wrong).
Still, given that this is probably Specter's last term in office, he does have to come to terms with one question -- does he want to be the man responsible for overturning Roe v. Wade? Some legacy that would be.