I thought this ad was interesting not because it was mean or brutal or "going for the jugular" as other people have portrayed it. I thought it was interesting because it suggested that the Obama campaign, unlike Democrats of yore, might get that the most underused weapon in Dem politics is ridicule.
Bob Casey didn't beat Santorum by over 17 points because of fond memories of his pop or the general fact that everyone named Bob Casey wins election in Pennsylvania, he beat him by 17 points because people turned Santorum into a joke.
And it isn't even all that hard.